.Pharmacolibrary.Drugs.C_CardiovascularSystem.C02D_ArteriolarSmoothMuscleAgentsActingOn.C02DB02_Hydralazine.Hydralazine_1

Information

name:Hydralazine_1
ATC code:C02DB02_1
route:intravenous
n-compartments1

Hydralazine is a vasodilator used primarily to treat hypertension and congestive heart failure. It acts by directly relaxing vascular smooth muscle, leading to decreased peripheral resistance. Hydralazine is still approved and used clinically, often as adjunct therapy or when first-line antihypertensive agents are unsuitable.

Pharmacokinetics

Pharmacokinetic parameters from intravenous administration in healthy adults.

References

  1. Chera-Aree, P, et al., & Wataganara, T (2020). Clinical Experiences of Intravenous Hydralazine and Labetalol for Acute Treatment of Severe Hypertension in Pregnant Thai Women. Journal of clinical pharmacology 60(12) 1662–1670. DOI:10.1002/jcph.1685 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32598488

  2. Crawford, MH, et al., & Kennedy, GT (1985). Determinants of systemic availability of oral hydralazine in heart failure. Clinical pharmacology and therapeutics 38(5) 538–543. DOI:10.1038/clpt.1985.220 PUBMED:https://pubmed.ncbi.nlm.nih.gov/4053489

Revisions


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