.Pharmacolibrary.Drugs.C_CardiovascularSystem.C03A_LowCeilingDiureticsThiazides.C03AB02_HydroflumethiazideAndPot.HydroflumethiazideAndPot .Pharmacolibrary.Drugs.C_CardiovascularSystem.C03A_LowCeilingDiureticsThiazides.C03AB02_HydroflumethiazideAndPot.HydroflumethiazideAndPot| name: | HydroflumethiazideAndPotassium | |
| ATC code: | C03AB02 | route: | oral |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 3.5 | L |
| clearance: | 100 | mL/min |
| other parameters in model implementation | ||
Hydroflumethiazide is a thiazide diuretic used primarily for the treatment of hypertension and edema associated with congestive heart failure, renal dysfunction, or liver cirrhosis. It is sometimes co-administered with potassium supplements to counteract potassium loss caused by diuretic treatment. Hydroflumethiazide alone is approved and in clinical use in a number of countries, but fixed-dose combinations with potassium are not widely approved as single pharmaceutical products.
No published pharmacokinetic studies specifically for the fixed-dose combination of hydroflumethiazide and potassium were identified. The following PK parameters are estimated for healthy adults based on data from hydroflumethiazide monotherapy.