.Pharmacolibrary.Drugs.C_CardiovascularSystem.C03C_HighCeilingDiuretics.C03CA04_Torasemide.Torasemide

Information

Torasemide (also spelled torsemide) is a loop diuretic used to reduce fluid overload and treat hypertension, heart failure, and edema, primarily by inhibiting the sodium-potassium-chloride cotransporter in the thick ascending limb of Henle's loop. It is currently approved and widely used in clinical practice as an alternative to furosemide.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after oral administration.

References

1. Pelligand, L, et al., & Jacobs, M (2020). Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Frontiers in veterinary science 7 151–None. DOI:10.3389/fvets.2020.00151 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32411731

2. Sherazi, AW, et al., & Rasool, MF (2024). A Systematic Critical Review of Clinical Pharmacokinetics of Torasemide. Therapeutic drug monitoring 46(3) 309–320. DOI:10.1097/FTD.0000000000001141 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38176856

Revisions

• 06/2025 initial generated model