.Pharmacolibrary.Drugs.C_CardiovascularSystem.C03D_AldosteroneAntagonistsAndOtherPotassiumSparingAg.C03DA01_Spironolactone.Spironolactone

Information

name:Spironolactone
ATC code:C03DA01
route:oral
n-compartments1

Spironolactone is a potassium-sparing diuretic and an antagonist of aldosterone. It is primarily used to treat conditions such as heart failure, hypertension, primary hyperaldosteronism, and edema associated with liver cirrhosis or nephrotic syndrome. It is also used for treatment of hirsutism and acne in women. Spironolactone is an approved drug and is commonly used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects following a single oral dose.

References

  1. Lass, J, et al., & Lutsar, I (2024). Pharmacokinetics of oral spironolactone in infants up to 2 years of age. European journal of clinical pharmacology 80(2) 239–248. DOI:10.1007/s00228-023-03599-w PUBMED:https://pubmed.ncbi.nlm.nih.gov/38041740

  2. Oishi, M, et al., & Sweeney, K (2017). Population Pharmacokinetics of Eplerenone in Japanese Patients With Chronic Heart Failure. Journal of clinical pharmacology 57(6) 730–738. DOI:10.1002/jcph.861 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28032902

  3. Chen, R, et al., & Xia, ZL (2013). Population pharmacokinetics of digoxin in elderly patients. European journal of drug metabolism and pharmacokinetics 38(2) 115–121. DOI:10.1007/s13318-012-0107-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23096939

Revisions


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