.Pharmacolibrary.Drugs.C_CardiovascularSystem.C03E_DiureticsAndPotassiumSparingAgentsInCombination.C03EA03_EpitizideAndPotassiumSpa.EpitizideAndPotassiumSpa .Pharmacolibrary.Drugs.C_CardiovascularSystem.C03E_DiureticsAndPotassiumSparingAgentsInCombination.C03EA03_EpitizideAndPotassiumSpa.EpitizideAndPotassiumSpa| name: | EpitizideAndPotassiumSparingAgents | |
| ATC code: | C03EA03 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 25 | mg |
| volume of distribution: | 20 | L |
| clearance: | 1.5 | L/h |
| other parameters in model implementation | ||
Combination of epitizide, a thiazide diuretic, with potassium-sparing agents (such as amiloride or triamterene). Used in the management of hypertension and edema when there is a risk of potassium loss. Marketed primarily as fixed-dose oral formulations. The combination is used today but is not universally available or approved in all countries.
No published pharmacokinetic models or studies with detailed parameters for epitizide and potassium-sparing combination could be found in the literature. Estimated parameters are provided based on similar thiazide/potassium-sparing combinations (e.g., hydrochlorothiazide-amiloride) for adults, oral administration.