.Pharmacolibrary.Drugs.C_CardiovascularSystem.C03E_DiureticsAndPotassiumSparingAgentsInCombination.C03EB02_BumetanideAndPotassiumSp.BumetanideAndPotassiumSp .Pharmacolibrary.Drugs.C_CardiovascularSystem.C03E_DiureticsAndPotassiumSparingAgentsInCombination.C03EB02_BumetanideAndPotassiumSp.BumetanideAndPotassiumSp| name: | BumetanideAndPotassiumSparingAgents |
| ATC code: | C03EB02 | route: | oral |
| n-compartments | 1 |
A fixed-dose combination of bumetanide, a potent loop diuretic, and potassium-sparing agents, used for the treatment of edema and hypertension. Bumetanide acts on the ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption, while potassium-sparing agents help prevent hypokalemia, a common side effect of loop diuretics. This combination is approved and used in clinical practice for patients requiring diuresis with prevention of potassium loss.
No published pharmacokinetic studies directly reporting parameters for the combined product of bumetanide and potassium-sparing agents. The following values are estimated based on published data for oral bumetanide and typical potassium-sparing agents in healthy adults.