.Pharmacolibrary.Drugs.C_CardiovascularSystem.C04A_PeripheralVasodilators.C04AD03_Pentoxifylline.Pentoxifylline .Pharmacolibrary.Drugs.C_CardiovascularSystem.C04A_PeripheralVasodilators.C04AD03_Pentoxifylline.Pentoxifylline| name: | Pentoxifylline |
| ATC code: | C04AD03 | route: | oral |
| n-compartments | 2 |
Pentoxifylline is a methylxanthine derivative that improves microcirculation and reduces blood viscosity. It is used clinically to treat peripheral vascular diseases such as intermittent claudication. Pentoxifylline is approved and in current clinical use in many countries for this indication.
Pharmacokinetic parameters reported in healthy adult volunteers after single oral dosing.
Nisi, A, et al., & Padrini, R (2013). Pharmacokinetics of pentoxifylline and its main metabolites in patients with different degrees of heart failure following a single dose of a modified-release formulation. Journal of clinical pharmacology 53(1) 51–57. DOI:10.1177/0091270011433435 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23400743
Paap, CM, et al., & Sack, MR (1996). Multiple-dose pharmacokinetics of pentoxifylline and its metabolites during renal insufficiency. The Annals of pharmacotherapy 30(7-8) 724–729. DOI:10.1177/106002809603000702 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8826548