.Pharmacolibrary.Drugs.C_CardiovascularSystem.C05A_AgentsForTreatmentOfHemorrhoidsAndAnalFissuresFo.C05AA01_Hydrocortisone.Hydrocortisone

Information

Hydrocortisone is a synthetic form of cortisol, a corticosteroid hormone produced by the adrenal gland. It is used for its anti-inflammatory and immunosuppressive properties in conditions such as adrenal insufficiency, severe allergies, asthma, and various autoimmune disorders. Hydrocortisone is approved and widely used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers, single oral dose administration

References

1. Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797

2. Werumeus Buning, J, et al., & van Beek, AP (2017). Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism: clinical and experimental 71 7–16. DOI:10.1016/j.metabol.2017.02.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28521880

3. Polito, A, et al., & Alvarez, JC (2016). Pharmacokinetics of oral fludrocortisone in septic shock. British journal of clinical pharmacology 82(6) 1509–1516. DOI:10.1111/bcp.13065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27416887

Revisions

• 06/2025 initial generated model