.Pharmacolibrary.Drugs.C_CardiovascularSystem.C05A_AgentsForTreatmentOfHemorrhoidsAndAnalFissuresFo.C05AX06_Phenylephrine.Phenylephrine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C05A_AgentsForTreatmentOfHemorrhoidsAndAnalFissuresFo.C05AX06_Phenylephrine.Phenylephrine| name: | Phenylephrine |
| ATC code: | C05AX06 | route: | oral |
| n-compartments | 1 |
Phenylephrine is a selective alpha-1 adrenergic receptor agonist primarily used as a decongestant, vasopressor, and mydriatic agent. It is approved for use in the management of nasal congestion, hypotension (especially during anesthesia), and to dilate pupils for ophthalmic procedures. Phenylephrine is commonly available in oral, intravenous, and ophthalmic formulations and remains in use today.
Pharmacokinetic parameters reported in healthy adult volunteers after a single 10 mg oral dose.
Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219
Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358
Vincent, J, et al., & Reid, JL (1986). Racial differences in drug responses--a comparative study of trimazosin and alpha 1-adrenoceptor responses in normotensive Caucasians and West Africans. British journal of clinical pharmacology 21(4) 401–408. DOI:10.1111/j.1365-2125.1986.tb05214.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3011048