.Pharmacolibrary.Drugs.C_CardiovascularSystem.C07A_BetaBlockingAgents.C07AA05_Propranolol.Propranolol

Information

Propranolol is a non-selective beta-adrenergic receptor blocker used for the management of hypertension, angina pectoris, arrhythmias, myocardial infarction, and for the prevention of migraine headaches. It is one of the first beta-blockers developed and is widely approved for clinical use today.

Pharmacokinetics

Reported pharmacokinetic parameters in healthy adult subjects following a single oral dose.

References

1. Kalam, MN, et al., & Ahmed, N (2020). Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review. Current drug metabolism 21(2) 89–105. DOI:10.2174/1389200221666200414094644 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32286940

2. Takechi, T, et al., & Ieiri, I (2018). Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma. Journal of clinical pharmacology 58(10) 1361–1370. DOI:10.1002/jcph.1149 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29746707

3. Olsen, GM, et al., & Drolet, BA (2020). Evaluating the Safety of Oral Propranolol Therapy in Patients With PHACE Syndrome. JAMA dermatology 156(2) 186–190. DOI:10.1001/jamadermatol.2019.3839 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31825455

Revisions

• 06/2025 initial generated model