.Pharmacolibrary.Drugs.C_CardiovascularSystem.C07A_BetaBlockingAgents.C07AA07_Sotalol.Sotalol

Information

Sotalol is a non-selective beta-adrenergic blocker with class III antiarrhythmic properties, used for the treatment of ventricular and supraventricular arrhythmias, including atrial fibrillation and ventricular tachycardia. It is approved and widely used today for rhythm control in various arrhythmias.

Pharmacokinetics

Pharmacokinetic parameters for healthy adult subjects, following oral administration.

References

1. Yellepeddi, VK, et al., & Watt, K (2025). Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias. CPT: pharmacometrics & systems pharmacology 14(4) 658–667. DOI:10.1002/psp4.13302 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39749676

2. Saul, JP, et al., & Hinderling, PH (2001). Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia. Clinical pharmacology and therapeutics 69(3) 145–157. DOI:10.1067/mcp.2001.113795 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11240979

3. Saul, JP, et al., & Hinderling, PH (2001). Single-dose pharmacokinetics of sotalol in a pediatric population with supraventricular and/or ventricular tachyarrhythmia. Journal of clinical pharmacology 41(1) 35–43. DOI:10.1177/00912700122009818 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11144992

Revisions

• 06/2025 initial generated model