.Pharmacolibrary.Drugs.C_CardiovascularSystem.C07A_BetaBlockingAgents.C07AB12_Nebivolol.Nebivolol

Information

Nebivolol is a cardioselective beta-1 adrenergic receptor blocker with vasodilating properties due to nitric oxide modulation. It is used for the management of hypertension and heart failure. Nebivolol is approved and commonly used in clinical practice primarily for the treatment of high blood pressure.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral administration of 5 mg nebivolol.

References

1. Luo, X, et al., & Cheng, Z (2015). No influence of CYP2D6*10 genotype and phenotype on the pharmacokinetics of nebivolol in healthy Chinese subjects. Journal of clinical pharmacy and therapeutics 40(5) 561–565. DOI:10.1111/jcpt.12310 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26214065

2. Deedwania, P, et al., & Brener, L (2013). Effects of add-on nebivolol on blood pressure and glucose parameters in hypertensive patients with prediabetes. Journal of clinical hypertension (Greenwich, Conn.) 15(4) 270–278. DOI:10.1111/jch.12071 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23551727

Revisions

• 06/2025 initial generated model