.Pharmacolibrary.Drugs.C_CardiovascularSystem.C07F_BetaBlockingAgentsOtherCombinations.C07FB13_MetoprololAndAmlodipine.MetoprololAndAmlodipine

Information

Combination of metoprolol, a beta-1 adrenergic blocker, and amlodipine, a dihydropyridine calcium channel blocker. Used to treat hypertension and angina pectoris. Both drugs are approved and widely used for cardiovascular diseases.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adult subjects based on individual drug profiles, as no published studies for the combination product are available.

References

1. Pham, P, et al., & Brown, JD (2020). Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function. JAMA network open 3(4) e203593–None. DOI:10.1001/jamanetworkopen.2020.3593 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32329770

2. Hill, K, et al., & Sood, MM (2022). Amiodarone, Verapamil, or Diltiazem Use With Direct Oral Anticoagulants and the Risk of Hemorrhage in Older Adults. CJC open 4(3) 315–323. DOI:10.1016/j.cjco.2021.11.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35386137

Revisions

• 06/2025 initial generated model