.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA03_Isradipine.Isradipine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA03_Isradipine.Isradipine| name: | Isradipine |
| ATC code: | C08CA03 | route: | oral |
| n-compartments | 2 |
Isradipine is a dihydropyridine calcium channel blocker used primarily for the management of hypertension (high blood pressure). It acts by relaxing vascular smooth muscle, leading to decreased peripheral resistance and lowered blood pressure. Isradipine was previously approved and marketed for clinical use but is now discontinued in several countries, including the United States.
Pharmacokinetic parameters reported for healthy adult volunteers following oral administration of immediate-release isradipine tablets.
Venuto, CS, et al., & Simuni, T (2021). Isradipine plasma pharmacokinetics and exposure-response in early Parkinson's disease. Annals of clinical and translational neurology 8(3) 603–612. DOI:10.1002/acn3.51300 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33460320
Wang, Y, et al., & Wang, L (2013). Pharmacokinetic properties of isradipine after single-dose and multiple-dose oral administration in Chinese volunteers: a randomized, open-label, parallel-group phase I study. Biomedical chromatography : BMC 27(12) 1664–1670. DOI:10.1002/bmc.2977 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23813620
Strauser, LM, et al., & Tobias, JD (2000). Initial experience with isradipine for the treatment of hypertension in children. Southern medical journal 93(3) 287–293. PUBMED:https://pubmed.ncbi.nlm.nih.gov/10728516