.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA04_Nicardipine.Nicardipine

Information

Nicardipine is a dihydropyridine calcium channel blocker used in the management of hypertension and angina pectoris. It works primarily by relaxing vascular smooth muscle, thus dilating blood vessels to reduce blood pressure. Nicardipine is approved and widely used for acute hypertension, including hypertensive emergencies and for short-term management of high blood pressure.

Pharmacokinetics

Healthy adult volunteers, single oral administration.

References

1. Zhang, GM, et al., & Lu, W (2008). [Population pharmacokinetics of tacrolimus in Chinese renal transplant patients]. Yao xue xue bao = Acta pharmaceutica Sinica 43(7) 695–701. PUBMED:https://pubmed.ncbi.nlm.nih.gov/18819472

2. Strauser, LM, et al., & Tobias, JD (2000). Initial experience with isradipine for the treatment of hypertension in children. Southern medical journal 93(3) 287–293. PUBMED:https://pubmed.ncbi.nlm.nih.gov/10728516

3. Porchet, HC, et al., & Dayer, P (1988). [Absence of polymorphism in individual response to the dihydropyridines nifedipine and (+/-)-nicardipine]. Schweizerische medizinische Wochenschrift 118(50) 1918–1920. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3222686

Revisions

• 06/2025 initial generated model