.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA09_Lacidipine.Lacidipine

Information

name:Lacidipine
ATC code:C08CA09
route:oral
compartments:2
dosage:4mg
volume of distribution:170L
clearance:55L/h
other parameters in model implementation

Lacidipine is a dihydropyridine calcium channel blocker used primarily for the treatment of hypertension. It acts by relaxing vascular smooth muscle and reducing peripheral resistance. It is approved and used clinically in several countries for the management of high blood pressure.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after single oral dosing.

References

  1. McCormack, PL, & Wagstaff, AJ (2003). Lacidipine: a review of its use in the management of hypertension. Drugs 63(21) 2327–2356. DOI:10.2165/00003495-200363210-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14524737

  2. Yang, B, et al., & Sun, J (2017). Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs. Asian journal of pharmaceutical sciences 12(1) 98–104. DOI:10.1016/j.ajps.2016.03.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32104318

  3. Hall, ST, et al., & Rizzini, P (1991). Clinical pharmacology of lacidipine. Journal of cardiovascular pharmacology 17 Suppl 4 S9–S13. PUBMED:https://pubmed.ncbi.nlm.nih.gov/1726014

Revisions


Generated at 2025-08-11T18:21:04Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos