.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA09_Lacidipine.Lacidipine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C08C_SelectiveCalciumChannelBlockersWithMainlyVascula.C08CA09_Lacidipine.Lacidipine| name: | Lacidipine |
| ATC code: | C08CA09 | route: | oral |
| n-compartments | 2 |
Lacidipine is a dihydropyridine calcium channel blocker used primarily for the treatment of hypertension. It acts by relaxing vascular smooth muscle and reducing peripheral resistance. It is approved and used clinically in several countries for the management of high blood pressure.
Pharmacokinetic parameters reported in healthy adult volunteers after single oral dosing.
McCormack, PL, & Wagstaff, AJ (2003). Lacidipine: a review of its use in the management of hypertension. Drugs 63(21) 2327–2356. DOI:10.2165/00003495-200363210-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14524737
Yang, B, et al., & Sun, J (2017). Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs. Asian journal of pharmaceutical sciences 12(1) 98–104. DOI:10.1016/j.ajps.2016.03.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32104318
Hall, ST, et al., & Rizzini, P (1991). Clinical pharmacology of lacidipine. Journal of cardiovascular pharmacology 17 Suppl 4 S9–S13. PUBMED:https://pubmed.ncbi.nlm.nih.gov/1726014