.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08D_SelectiveCalciumChannelBlockersWithDirectCardiac.C08DB01_Diltiazem.Diltiazem

Information

Diltiazem is a non-dihydropyridine calcium channel blocker (class IV antiarrhythmic) used to treat hypertension, angina pectoris, and certain types of cardiac arrhythmias such as atrial fibrillation or supraventricular tachycardia. It is an approved prescription medication and widely used clinically.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers (both sexes, age 18–65 years) after oral administration in a crossover study.

References

1. Murata, K, et al., & Samejima, M (1989). Pharmacokinetics of an oral sustained-release diltiazem preparation. Journal of pharmaceutical sciences 78(11) 960–963. DOI:10.1002/jps.2600781116 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2621582

2. Xu, Y, et al., & Shin, JI (2022). Concomitant Use of Diltiazem With Direct Oral Anticoagulants and Bleeding Risk in Atrial Fibrillation. Journal of the American Heart Association 11(14) e025723–None. DOI:10.1161/JAHA.122.025723 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35861836

3. Guan, XF, et al., & Zuo, XC (2018). Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients. European journal of drug metabolism and pharmacokinetics 43(1) 55–62. DOI:10.1007/s13318-017-0425-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/28646274

Revisions

• 06/2025 initial generated model