.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08E_NonSelectiveCalciumChannelBlockers.C08EX02_Perhexiline.Perhexiline .Pharmacolibrary.Drugs.C_CardiovascularSystem.C08E_NonSelectiveCalciumChannelBlockers.C08EX02_Perhexiline.Perhexiline| name: | Perhexiline | |
| ATC code: | C08EX02 | route: | oral |
| compartments: | 2 | |
| dosage: | 200 | mg |
| volume of distribution: | 20 | L |
| clearance: | 0.96 | L/h/kg |
| other parameters in model implementation | ||
Perhexiline is an antianginal agent that inhibits carnitine palmitoyltransferase-1 and -2, thereby modulating cardiac metabolism. It was used for the management of angina pectoris and some other cardiovascular indications but its use dropped sharply due to concerns of hepatotoxicity and neuropathy; in some countries it remains available under restricted conditions.
Pharmacokinetics reported in adult patients with angina pectoris, after oral administration, steady-state, mixed male and female, normal hepatic and renal function.
Gould, BJ, et al., & Parke, DV (1986). Stereoselective pharmacokinetics of perhexiline. Xenobiotica; the fate of foreign compounds in biological systems 16(5) 491–502. DOI:10.3109/00498258609050254 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3739369