.Pharmacolibrary.Drugs.C_CardiovascularSystem.C08E_NonSelectiveCalciumChannelBlockers.C08EX02_Perhexiline.Perhexiline

Information

Perhexiline is an antianginal agent that inhibits carnitine palmitoyltransferase-1 and -2, thereby modulating cardiac metabolism. It was used for the management of angina pectoris and some other cardiovascular indications but its use dropped sharply due to concerns of hepatotoxicity and neuropathy; in some countries it remains available under restricted conditions.

Pharmacokinetics

Pharmacokinetics reported in adult patients with angina pectoris, after oral administration, steady-state, mixed male and female, normal hepatic and renal function.

References

1. Gould, BJ, et al., & Parke, DV (1986). Stereoselective pharmacokinetics of perhexiline. Xenobiotica; the fate of foreign compounds in biological systems 16(5) 491–502. DOI:10.3109/00498258609050254 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3739369

Revisions

• 06/2025 initial generated model