.Pharmacolibrary.Drugs.C_CardiovascularSystem.C09A_AceInhibitorsPlain.C09AA02_Enalapril.Enalapril

Information

Enalapril is an angiotensin-converting enzyme (ACE) inhibitor used primarily for the treatment of hypertension, heart failure, and asymptomatic left ventricular dysfunction. It is an approved and widely prescribed medication for these indications.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after single oral administration.

References

1. Tian, L, et al., & Li, Y (2011). Effect of organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphism on the single- and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men. Clinical therapeutics 33(5) 655–663. DOI:10.1016/j.clinthera.2011.04.018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21665049

2. Ding, PY, et al., & Liao, W (2000). Does Chinese ethnicity affect the pharmacokinetics and pharmacodynamics of angiotensin-converting enzyme inhibitors?. Journal of human hypertension 14(3) 163–170. DOI:10.1038/sj.jhh.1000856 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10694829

3. DiBianco, R (1986). Adverse reactions with angiotensin converting enzyme (ACE) inhibitors. Medical toxicology 1(2) 122–141. DOI:10.1007/BF03259832 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3023783

Revisions

• 06/2025 initial generated model