.Pharmacolibrary.Drugs.C_CardiovascularSystem.C09B_AceInhibitorsCombinations.C09BB07_RamiprilAndAmlodipine.RamiprilAndAmlodipine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C09B_AceInhibitorsCombinations.C09BB07_RamiprilAndAmlodipine.RamiprilAndAmlodipine| name: | RamiprilAndAmlodipine | |
| ATC code: | C09BB07 | |
| route: | oral | |
| compartments: | 2 | |
| dosage: | 5 | mg |
| volume of distribution: | 70 | L |
| clearance: | 45 | L/h |
| other parameters in model implementation | ||
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor and amlodipine is a dihydropyridine calcium channel blocker. This fixed dose combination is used for the treatment of hypertension and/or cardiovascular risk reduction. Both drugs are widely approved and in current clinical use.
Estimated pharmacokinetic parameters for orally administered ramipril and amlodipine in adults based on the known PK profiles of each agent in healthy subjects.