.Pharmacolibrary.Drugs.C_CardiovascularSystem.C09B_AceInhibitorsCombinations.C09BX04_PerindoprilBisoprololAnd.PerindoprilBisoprololAnd .Pharmacolibrary.Drugs.C_CardiovascularSystem.C09B_AceInhibitorsCombinations.C09BX04_PerindoprilBisoprololAnd.PerindoprilBisoprololAnd| name: | PerindoprilBisoprololAndAmlodipine | |
| ATC code: | C09BX04 | |
| route: | oral | |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 75 | L |
| clearance: | 13 | L/h |
| other parameters in model implementation | ||
This fixed-dose combination contains perindopril (an ACE inhibitor), bisoprolol (a selective beta1-blocker), and amlodipine (a calcium channel blocker). The combination is used for the management of hypertension and prevention of cardiovascular events, especially in patients who may benefit from multi-mechanism antihypertensive therapy. It is currently used and approved in various regions.
Pharmacokinetic parameters estimated based on published data of the individual components in healthy adults; no direct publication for the fixed-dose triple combination found.