.Pharmacolibrary.Drugs.C_CardiovascularSystem.C09C_AngiotensinIiReceptorBlockersArbsPlain.C09CA03_Valsartan.Valsartan

Information

name:Valsartan
ATC code:C09CA03
route:oral
n-compartments2

Valsartan is an angiotensin II receptor blocker (ARB) used in the management of hypertension, heart failure, and to improve survival after myocardial infarction. It is approved for use by regulatory agencies globally and is in active clinical use.

Pharmacokinetics

Pharmacokinetic model for healthy adult volunteers after single oral dose administration.

References

  1. Ngo, L, et al., & Lee, YB (2018). Effects of hydrochlorothiazide and amlodipine on single oral dose pharmacokinetics of valsartan in healthy Korean subjects: Population model-based approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 118 154–164. DOI:10.1016/j.ejps.2018.03.031 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29604332

  2. Sioufi, A, et al., & Lloyd, P (1998). The effect of age on the pharmacokinetics of valsartan. Biopharmaceutics & drug disposition 19(4) 237–244. DOI:10.1002/(sici)1099-081x(199805)19:4<237::aid-bdd100>3.0.co;2-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9604123

  3. Iqbal, M, et al., & Sharma, PL (2010). Pharmacokinetics and bioequivalence study of three oral formulations of valsartan 160 mg: a single-dose, randomized, open-label, three-period crossover comparison in healthy Indian male volunteers. Clinical therapeutics 32(3) 588–596. DOI:10.1016/j.clinthera.2010.03.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20399995

Revisions


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