name: | Fimasartan |
ATC code: | C09CA10 | route: | oral |
n-compartments | 2 |
Fimasartan is an angiotensin II receptor antagonist (ARB) used for the treatment of hypertension, helping to lower blood pressure and reduce the risk of cardiovascular events. It is approved and used in several countries, particularly in South Korea.
Pharmacokinetic parameters in healthy adult volunteers following oral administration.
Chi, YH, et al., & Kim, SL (2011). Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects. American journal of cardiovascular drugs : drugs, devices, and other interventions 11(5) 335–346. DOI:10.2165/11593840-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21910510
Kim, TH, et al., & Shin, BS (2015). Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans. The AAPS journal 17(5) 1210–1223. DOI:10.1208/s12248-015-9764-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25990964
Bulitta, JB, et al., & Shin, BS (2017). Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 107 32–44. DOI:10.1016/j.ejps.2017.06.008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28599987