.Pharmacolibrary.Drugs.C_CardiovascularSystem.C09D_AngiotensinIiReceptorBlockersArbsCombinations.C09DB01_ValsartanAndAmlodipine.ValsartanAndAmlodipine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C09D_AngiotensinIiReceptorBlockersArbsCombinations.C09DB01_ValsartanAndAmlodipine.ValsartanAndAmlodipine| name: | ValsartanAndAmlodipine |
| ATC code: | C09DB01 | route: | oral |
| n-compartments | 2 |
Valsartan and amlodipine is a fixed-dose combination of two antihypertensive agents: valsartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker. The combination is widely approved and used for the treatment of hypertension to lower blood pressure and reduce the risk of cardiovascular events.
Estimated pharmacokinetic parameters for healthy adult subjects after oral administration of fixed-dose combination tablets. No direct publication was found reporting population PK models for the combination tablet, so estimates are from separate published PK data of valsartan and amlodipine monotherapies.
Tian, M, et al., & Yang, S (2025). Pharmacokinetics and Bioequivalence of Two Fixed-Dose Combination Tablets of Valsartan/Amlodipine (80/5 Mg) in Healthy Chinese Subjects. Drug design, development and therapy 19 11–22. DOI:10.2147/DDDT.S485851 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39781445