.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AA01_Simvastatin.Simvastatin

Information

Simvastatin is a lipid-lowering medication of the statin class, used primarily to treat high cholesterol and reduce the risk of cardiovascular disease. It inhibits HMG-CoA reductase, a key enzyme involved in the mevalonate pathway of cholesterol synthesis. Simvastatin is approved and widely used today.

Pharmacokinetics

Pharmacokinetic parameters of simvastatin in healthy adult subjects after single oral dose administration.

References

1. Ogungbenro, K, et al., & Galetin, A (2019). A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents. European journal of clinical pharmacology 75(9) 1227–1235. DOI:10.1007/s00228-019-02697-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/31172248

2. Kim, MS, & Baek, IH (2021). Pharmacokinetic analysis of two different doses of simvastatin following oral administration in dogs. Journal of veterinary pharmacology and therapeutics 44(3) 333–341. DOI:10.1111/jvp.12944 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33368422

3. Zhou, Q, et al., & Zeng, S (2013). Simvastatin pharmacokinetics in healthy Chinese subjects and its relations with CYP2C9, CYP3A5, ABCB1, ABCG2 and SLCO1B1 polymorphisms. Die Pharmazie 68(2) 124–128. PUBMED:https://pubmed.ncbi.nlm.nih.gov/23469684

Revisions

• 06/2025 initial generated model