.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AB01_Clofibrate.Clofibrate

Information

Clofibrate is a fibrate drug previously used as a lipid-lowering agent for the treatment of hyperlipidemia and to reduce cholesterol and triglyceride levels. It acts as a peroxisome proliferator-activated receptor (PPAR) agonist. Clofibrate is largely discontinued or withdrawn in many countries due to safety concerns and limited efficacy.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after single oral dose.

References

1. McNamara, DJ, et al., & Ahrens, EH (1980). Cholesterol absorption in man: effect of administration of clofibrate and/or cholestyramine. Journal of lipid research 21(8) 1058–1064. PUBMED:https://pubmed.ncbi.nlm.nih.gov/7462801

Revisions

• 06/2025 initial generated model