.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AC01_Colestyramine.Colestyramine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AC01_Colestyramine.Colestyramine| name: | Colestyramine |
| ATC code: | C10AC01 | route: | oral |
| n-compartments | 1 |
Colestyramine (also known as cholestyramine) is an anion-exchange resin used to lower cholesterol levels and to treat pruritus associated with partial biliary obstruction. It is also used for the management of bile acid-induced diarrhea. The drug is administered orally and is generally considered safe, though it is largely superseded by more modern lipid-lowering agents for primary hypercholesterolemia. It is still approved and used clinically today for specified indications.
Colestyramine is a non-absorbed resin and acts locally in the gastrointestinal tract; systemic pharmacokinetic parameters (e.g. bioavailability, volume of distribution, clearance) are not applicable, as it is not systemically absorbed in healthy adults.