.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AX01_Dextrothyroxine.Dextrothyroxine .Pharmacolibrary.Drugs.C_CardiovascularSystem.C10A_LipidModifyingAgentsPlain.C10AX01_Dextrothyroxine.Dextrothyroxine| name: | Dextrothyroxine |
| ATC code: | C10AX01 | route: |
| n-compartments | 0 |
Dextrothyroxine is a synthetic stereoisomer of thyroxine (T4), previously investigated for use as a lipid-lowering agent to treat hypercholesterolemia. It is no longer in clinical use or approved for therapy due to unfavorable risk-benefit profile and adverse cardiac effects.
No formal pharmacokinetic models with numerical parameters for dextrothyroxine in humans have been published in accessible literature. Pharmacokinetics may be similar to levothyroxine, with slow oral absorption and long half-life, but precise values for absorption rate constant (ka), clearance, or compartmental distribution are not reported.