.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10B_LipidModifyingAgentsCombinations.C10BA11_PravastatinAndEzetimibe.PravastatinAndEzetimibe .Pharmacolibrary.Drugs.C_CardiovascularSystem.C10B_LipidModifyingAgentsCombinations.C10BA11_PravastatinAndEzetimibe.PravastatinAndEzetimibe| name: | PravastatinAndEzetimibe |
| ATC code: | C10BA11 | route: | oral |
| n-compartments | 1 |
Pravastatin and ezetimibe is a fixed-dose combination medication used for the treatment of hypercholesterolemia and mixed dyslipidemia. Pravastatin is an HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver, while ezetimibe is a cholesterol absorption inhibitor that decreases cholesterol uptake in the intestine. This combination is approved and widely used when treatment with diet and a single agent is inadequate.
No population pharmacokinetic models combining pravastatin and ezetimibe as a fixed-dose combination have been reported in the published literature. Therefore, the following parameters represent an estimated profile based on data from individual components in healthy adult subjects.