.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10B_LipidModifyingAgentsCombinations.C10BX01_SimvastatinAndAcetylsali.SimvastatinAndAcetylsali

Information

name:SimvastatinAndAcetylsalicylicAcid
ATC code:C10BX01
route:oral
n-compartments1

Simvastatin and acetylsalicylic acid is a fixed combination of two agents: simvastatin, a lipid-lowering statin used to decrease plasma LDL cholesterol and prevent cardiovascular events, and acetylsalicylic acid (aspirin), an antiplatelet agent used to reduce the risk of thrombosis. This drug combination is approved and used to decrease the risk of cardiovascular events in high-risk patients.

Pharmacokinetics

No direct clinical pharmacokinetic studies available for the fixed combination of simvastatin and acetylsalicylic acid. Estimated parameters are based on the known pharmacokinetics of individual components in healthy adults.

References

  1. Danielak, D, et al., & Główka, F (2018). Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins. Drugs 78(11) 1105–1112. DOI:10.1007/s40265-018-0947-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/30003466

  2. Pincus, KJ, & Hynicka, LM (2013). Prophylaxis of thromboembolic events in patients with nephrotic syndrome. The Annals of pharmacotherapy 47(5) 725–734. DOI:10.1345/aph.1R530 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23613095

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos