.Pharmacolibrary.Drugs.C_CardiovascularSystem.C10B_LipidModifyingAgentsCombinations.C10BX08_AtorvastatinAndAcetylsalicylicAc.AtorvastatinAndAcetylsalicylicAc

Information

Atorvastatin and acetylsalicylic acid is a fixed-dose combination drug containing atorvastatin, a statin used to lower cholesterol levels, and acetylsalicylic acid (aspirin), an antiplatelet agent used for cardiovascular prevention. This combination is used to reduce cardiovascular risk in patients with established atherosclerotic disease or high cardiovascular risk. It is an approved therapy in various countries.

Pharmacokinetics

Estimated pharmacokinetic parameters for single oral dose administration in healthy adults, based on available data for individual components (atorvastatin and acetylsalicylic acid) as no direct combo PK data is published.

References

1. Danielak, D, et al., & Główka, F (2018). Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins. Drugs 78(11) 1105–1112. DOI:10.1007/s40265-018-0947-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/30003466

2. Pincus, KJ, & Hynicka, LM (2013). Prophylaxis of thromboembolic events in patients with nephrotic syndrome. The Annals of pharmacotherapy 47(5) 725–734. DOI:10.1345/aph.1R530 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23613095

Revisions

• 06/2025 initial generated model