.Pharmacolibrary.Drugs.D_Dermatologicals.D01A_AntifungalsForTopicalUse.D01AC02_Miconazole.Miconazole

Information

name:Miconazole
ATC code:D01AC02
route:oral
n-compartments1

Miconazole is an imidazole antifungal medication primarily used to treat superficial fungal infections, such as athlete's foot, ringworm, and candidiasis (including oral and vaginal candidiasis). It functions by inhibiting ergosterol synthesis, disrupting fungal cell membrane integrity. Miconazole is approved and widely used in topical, oral, and occasionally intravenous formulations for the treatment of fungal infections in various countries.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers following oral administration.

References

  1. Simmons, KB, et al., & Merkatz, R (2018). Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring: a randomized, crossover drug-drug interaction study. Contraception 97(3) 270–276. DOI:10.1016/j.contraception.2017.10.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29097225

  2. Lalla, RV, & Bensadoun, RJ (2011). Miconazole mucoadhesive tablet for oropharyngeal candidiasis. Expert review of anti-infective therapy 9(1) 13–17. DOI:10.1586/eri.10.152 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21171872

  3. Hayashi, Y, et al., & Yamada, Y (1995). [Study of serial bronchoalveolar lavage in patients with aspergilloma: cell reaction at the affected sites and penetration of miconazole and flucytosine into the lesion]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 69(5) 517–523. DOI:10.11150/kansenshogakuzasshi1970.69.517 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7602184

Revisions


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