.Pharmacolibrary.Drugs.D_Dermatologicals.D01A_AntifungalsForTopicalUse.D01AC15_Fluconazole.Fluconazole

Information

name:Fluconazole
ATC code:D01AC15
route:oral
n-compartments1

Fluconazole is a triazole antifungal medication used to treat and prevent a variety of fungal and yeast infections, including candidiasis and cryptococcal meningitis. It is approved for use in many countries and is commonly prescribed both for systemic and superficial mycoses.

Pharmacokinetics

Pharmacokinetic parameters as reported in healthy adult volunteers after single oral dose.

References

  1. Momper, JD, et al., & Benjamin, DK (2016). Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams. Antimicrobial agents and chemotherapy 60(9) 5539–5545. DOI:10.1128/AAC.00963-16 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27401564

  2. Stott, KE, et al., & Hope, W (2018). Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis. Antimicrobial agents and chemotherapy 62(9) –. DOI:10.1128/AAC.00885-18 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29914943

  3. Chen, Y, et al., & Krishna, G (2022). Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults. Cancer chemotherapy and pharmacology 90(4) 325–334. DOI:10.1007/s00280-022-04464-w PUBMED:https://pubmed.ncbi.nlm.nih.gov/36001108

Revisions


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