.Pharmacolibrary.Drugs.D_Dermatologicals.D01A_AntifungalsForTopicalUse.D01AE15_Terbinafine.Terbinafine

Information

name:Terbinafine
ATC code:D01AE15
route:oral
n-compartments2

Terbinafine is an allylamine antifungal agent primarily used for the treatment of dermatophyte infections such as onychomycosis (fungal nail infections) and tinea infections of the skin. It acts by inhibiting squalene epoxidase, a key enzyme in fungal ergosterol synthesis. Terbinafine is approved and widely used today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers (both sexes), following single and multiple oral doses.

References

  1. Scher, RK (1999). Onychomycosis: therapeutic update. Journal of the American Academy of Dermatology 40(6 Pt 2) S21–S26. DOI:10.1016/s0190-9622(99)70397-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10367912

  2. Gupta, AK, et al., & Cooper, EA (2003). The efficacy and safety of terbinafine in children. Journal of the European Academy of Dermatology and Venereology : JEADV 17(6) 627–640. DOI:10.1046/j.1468-3083.2003.00691.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/14761128

  3. Gupta, AK, et al., & Cooper, EA (2024). Efinaconazole 10% solution: a comprehensive review of its use in the treatment of onychomycosis. Expert opinion on pharmacotherapy 25(15) 1983–1998. DOI:10.1080/14656566.2024.2416924 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39394930

Revisions


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