.Pharmacolibrary.Drugs.D_Dermatologicals.D01A_AntifungalsForTopicalUse.D01AE21_Flucytosine.Flucytosine

Information

name:Flucytosine
ATC code:D01AE21
route:oral
n-compartments1

Flucytosine is an antifungal medication used primarily for the treatment of serious fungal infections, such as cryptococcal meningitis and systemic candidiasis, often in combination with other agents like amphotericin B. It is still in clinical use for these indications.

Pharmacokinetics

Typical pharmacokinetics in adult patients with normal renal function; reported parameters are from multiple clinical studies of oral administration.

References

  1. Kim, HY, et al., & Alffenaar, JW (2020). Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review. Frontiers in pharmacology 11 894–None. DOI:10.3389/fphar.2020.00894 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32595511

  2. Dupont, B (2001). [Choice and use of antifungal drugs]. La Revue du praticien 51(7) 752–757. PUBMED:https://pubmed.ncbi.nlm.nih.gov/11387672

  3. Hayashi, Y, et al., & Yamada, Y (1995). [Study of serial bronchoalveolar lavage in patients with aspergilloma: cell reaction at the affected sites and penetration of miconazole and flucytosine into the lesion]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 69(5) 517–523. DOI:10.11150/kansenshogakuzasshi1970.69.517 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7602184

Revisions


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