.Pharmacolibrary.Drugs.D_Dermatologicals.D02B_ProtectivesAgainstUvRadiation.D02BB01_Betacarotene.Betacarotene .Pharmacolibrary.Drugs.D_Dermatologicals.D02B_ProtectivesAgainstUvRadiation.D02BB01_Betacarotene.Betacarotene| name: | Betacarotene |
| ATC code: | D02BB01 | route: | oral |
| n-compartments | 1 |
Betacarotene is a provitamin A carotenoid, an antioxidant compound used primarily as a dietary supplement to prevent vitamin A deficiency and related disorders. It is not approved as a primary therapeutic agent for any disease, but is widely used in dermatology, ophthalmology, and as a nutritional supplement.
Estimated pharmacokinetic parameters for healthy adult individuals after oral administration, as direct human PK models for betacarotene are not systematically reported in published literature.
Woutersen, RA, et al., & Feron, VJ (1999). Safety evaluation of synthetic beta-carotene. Critical reviews in toxicology 29(6) 515–542. DOI:10.1080/10408449991349267 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10628775
Newcomb, SA, et al., & Davis, TP (1990). Endogenous levels of beta-carotene in human buccal mucosa cells by reversed-phase high-performance liquid chromatography. Journal of chromatography 526(1) 47–58. DOI:10.1016/s0378-4347(00)82482-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2341545