.Pharmacolibrary.Drugs.D_Dermatologicals.D04A_AntipruriticsInclAntihistaminesAnestheticsEtc.D04AA10_Promethazine.Promethazine

Information

Promethazine is a first-generation antihistamine of the phenothiazine family, primarily used as an antiemetic, sedative, antiallergic, and for motion sickness. It is approved for use in many countries and is commonly prescribed for allergic reactions, nausea, and insomnia.

Pharmacokinetics

Pharmacokinetics reported for healthy adult subjects following single 25 mg oral dose.

References

1. Paton, DM, & Webster, DR (1985). Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 10(6) 477–497. DOI:10.2165/00003088-198510060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2866055

2. Kirchheiner, J, et al., & Brockmöller, J (2003). Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics 13(10) 619–626. DOI:10.1097/00008571-200310000-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14515060

Revisions

• 06/2025 initial generated model