.Pharmacolibrary.Drugs.D_Dermatologicals.D04A_AntipruriticsInclAntihistaminesAnestheticsEtc.D04AB06_Tetracaine.Tetracaine .Pharmacolibrary.Drugs.D_Dermatologicals.D04A_AntipruriticsInclAntihistaminesAnestheticsEtc.D04AB06_Tetracaine.Tetracaine| name: | Tetracaine | |
| ATC code: | D04AB06 | route: | topical |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 8 | mL/min/kg |
| other parameters in model implementation | ||
Tetracaine is an ester-type local anesthetic used primarily for topical anesthesia of the eye, nose, and throat, and occasionally for spinal anesthesia. It acts as a sodium channel blocker, preventing nerve impulse conduction. It is approved and still used clinically, especially as a topical and spinal anesthetic.
Estimated pharmacokinetic parameters based on general properties of ester-type local anesthetics. No specific published human PK studies found for tetracaine.
O'Brien, L, et al., & Koren, G (2005). A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain. Paediatric drugs 7(1) 41–54. DOI:10.2165/00148581-200507010-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15777110