.Pharmacolibrary.Drugs.D_Dermatologicals.D04A_AntipruriticsInclAntihistaminesAnestheticsEtc.D04AX01_Doxepin.Doxepin

Information

Doxepin is a tricyclic antidepressant (TCA) primarily used for the treatment of major depressive disorder, anxiety disorders, and insomnia. It is also indicated for pruritus and chronic urticaria. The drug acts mainly by inhibiting the reuptake of norepinephrine and serotonin. Doxepin is approved and is in clinical use, particularly for depression and insomnia.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral administration.

References

1. el-Yazigi, A, & Chaleby, K (1988). Steady-state kinetics of doxepin and imipramine in Saudi patients with interethnic comparison. Psychopharmacology 95(1) 63–67. DOI:10.1007/BF00212768 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3133701

2. Kirchheiner, J, et al., & Brockmöller, J (2002). Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics 12(7) 571–580. DOI:10.1097/00008571-200210000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12360109

3. Gosselin, C, & Ancill, RJ (1989). Comparative plasma levels of doxepin and desipramine in the elderly. Canadian journal of psychiatry. Revue canadienne de psychiatrie 34(9) 921–924. DOI:10.1177/070674378903400913 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2611758

Revisions

• 06/2025 initial generated model