.Pharmacolibrary.Drugs.D_Dermatologicals.D05A_AntipsoriaticsForTopicalUse.D05AX03_Calcitriol.Calcitriol .Pharmacolibrary.Drugs.D_Dermatologicals.D05A_AntipsoriaticsForTopicalUse.D05AX03_Calcitriol.Calcitriol| name: | Calcitriol |
| ATC code: | D05AX03 | route: | oral |
| n-compartments | 2 |
Calcitriol is the active form of vitamin D3 (1,25-dihydroxycholecalciferol). It is primarily used to manage hypocalcemia, secondary hyperparathyroidism, and metabolic bone diseases such as osteoporosis and chronic kidney disease. Calcitriol is an approved drug, used in both oral and intravenous forms.
Pharmacokinetics in healthy adult volunteers after single oral administration.
Linglart, A, et al., & Carpenter, TO (2022). Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia. The Journal of clinical endocrinology and metabolism 107(3) 813–824. DOI:10.1210/clinem/dgab729 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34636899
Moe, SM, et al., & Peacock, M (1998). Safety and efficacy of pulse and daily calcitriol in patients on CAPD: a randomized trial. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 13(5) 1234–1241. DOI:10.1093/ndt/13.5.1234 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9623560
Best, CM, et al., & O'Brien, KO (2022). Vitamin D kinetics in nonpregnant and pregnant women after a single oral dose of trideuterated vitamin D. The Journal of steroid biochemistry and molecular biology 216 106034–None. DOI:10.1016/j.jsbmb.2021.106034 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34843870