.Pharmacolibrary.Drugs.D_Dermatologicals.D06A_AntibioticsForTopicalUse.D06AA02_Chlortetracycline.Chlortetracycline

Information

name:Chlortetracycline
ATC code:D06AA02
route:oral
n-compartments1

Chlortetracycline is a broad-spectrum tetracycline antibiotic primarily used for topical treatment of skin infections and for veterinary purposes. It was formerly used systemically in humans but is now largely replaced by other tetracyclines. Currently, its main human use is in ophthalmic ointments and for superficial skin infections. Chlortetracycline is not widely used systemically in clinical human medicine today.

Pharmacokinetics

Estimated pharmacokinetic model for adult humans, oral route, as no dedicated human systemic PK studies with reported parameters exist. Values inferred from pharmacokinetic knowledge of tetracyclines, as no direct published PK study for chlortetracycline in humans is identified.

References

  1. Zhang, Y, et al., & Yu, M (2022). Florfenicol/Chlortetracycline Effect on Pharmacodynamic Indices for Mutant Selection of . Microbial drug resistance (Larchmont, N.Y.) 28(7) 832–840. DOI:10.1089/mdr.2022.0008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35723674

  2. Cazer, CL, et al., & Gröhn, YT (2018). Expanding behavior pattern sensitivity analysis with model selection and survival analysis. BMC veterinary research 14(1) 355–None. DOI:10.1186/s12917-018-1674-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/30453986

  3. Cazer, CL, et al., & Gröhn, YT (2017). Monte Carlo Simulations Suggest Current Chlortetracycline Drug-Residue Based Withdrawal Periods Would Not Control Antimicrobial Resistance Dissemination from Feedlot to Slaughterhouse. Frontiers in microbiology 8 1753–None. DOI:10.3389/fmicb.2017.01753 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29033901

Revisions


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