.Pharmacolibrary.Drugs.D_Dermatologicals.D06A_AntibioticsForTopicalUse.D06AX15_Rifamycin.Rifamycin

Information

name:Rifamycin
ATC code:D06AX15
route:oral
n-compartments1

Rifamycin is a semi-synthetic antibiotic belonging to the rifamycin class. It is used primarily as a topical antibacterial agent for the treatment of skin infections and some gastrointestinal infections (as rifamycin sodium or rifaximin). It is no longer widely used systemically due to resistance and other derivatives (like rifampicin) are preferred. Rifamycin is still approved for certain topical and GI indications.

Pharmacokinetics

Estimated pharmacokinetic parameters for topical or oral gastrointestinal use in adult population as no published compartmental PK model available for the rifamycin active substance.

References

  1. Hoy, SM (2019). Rifamycin SV MMX. Clinical drug investigation 39(7) 691–697. DOI:10.1007/s40261-019-00808-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31172447

  2. Scarpignato, C, & Pelosini, I (2005). Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy 51 Suppl 1 36–66. DOI:10.1159/000081990 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15855748

  3. Zheng, C, et al., & Gao, F (2017). Clinical and pharmacological hallmarks of rifapentine's use in diabetes patients with active and latent tuberculosis: do we know enough?. Drug design, development and therapy 11 2957–2968. DOI:10.2147/DDDT.S146506 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29066867

Revisions


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