.Pharmacolibrary.Drugs.D_Dermatologicals.D07A_CorticosteroidsPlain.D07AB19_Dexamethasone.Dexamethasone

Information

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It is used as an anti-inflammatory and immunosuppressant in conditions such as allergies, asthma, rheumatoid arthritis, severe COVID-19, various cancers, and cerebral edema. Dexamethasone is approved and widely used both in hospital and outpatient settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.

References

1. Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865

2. Wang, X, et al., & Kansra, V (2019). Population Pharmacokinetics of Rolapitant in Patients With Chemotherapy-Induced Nausea and Vomiting. Clinical pharmacology in drug development 8(7) 850–860. DOI:10.1002/cpdd.733 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31418538

3. Nakade, S, et al., & Miyata, Y (2008). Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer chemotherapy and pharmacology 63(1) 75–83. DOI:10.1007/s00280-008-0713-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/18317761

Revisions

• 06/2025 initial generated model