.Pharmacolibrary.Drugs.D_Dermatologicals.D07A_CorticosteroidsPlain.D07AB19_Dexamethasone.Dexamethasone_1

Information

name:Dexamethasone_1
ATC code:D07AB19_1
route:intravenous
n-compartments2

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It is used as an anti-inflammatory and immunosuppressant in conditions such as allergies, asthma, rheumatoid arthritis, severe COVID-19, various cancers, and cerebral edema. Dexamethasone is approved and widely used both in hospital and outpatient settings.

Pharmacokinetics

PK parameters for intravenous bolus administration in healthy adults.

References

  1. Li, L, et al., & Endeman, H (2023). Population pharmacokinetics of dexamethasone in critically ill COVID-19 patients: Does inflammation play a role?. Journal of critical care 78 154395–None. DOI:10.1016/j.jcrc.2023.154395 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37542750

  2. Guthrie, S (1991). The impact of dexamethasone pharmacokinetics on the DST: a review. Psychopharmacology bulletin 27(4) 565–576. PUBMED:https://pubmed.ncbi.nlm.nih.gov/1813902

  3. Nijstad, AL, et al., & Zwaan, CM (2022). Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 30(12) 9991–9999. DOI:10.1007/s00520-022-07423-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36287279

Revisions


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