.Pharmacolibrary.Drugs.D_Dermatologicals.D07X_CorticosteroidsOtherCombinations.D07XA01_Hydrocortisone.Hydrocortisone_1 .Pharmacolibrary.Drugs.D_Dermatologicals.D07X_CorticosteroidsOtherCombinations.D07XA01_Hydrocortisone.Hydrocortisone_1| name: | Hydrocortisone_1 |
| ATC code: | D07XA01_1 | route: | oral |
| n-compartments | 1 |
Hydrocortisone is a corticosteroid hormone (glucocorticoid) that is also administered orally to treat adrenocortical insufficiency and related disorders.
PK parameters estimated/typical for oral administration in healthy adults (no precise source for this dose/route in published compartmental model).
Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797
Werumeus Buning, J, et al., & van Beek, AP (2017). Pharmacokinetics of oral hydrocortisone - Results and implications from a randomized controlled trial. Metabolism: clinical and experimental 71 7–16. DOI:10.1016/j.metabol.2017.02.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28521880
Polito, A, et al., & Alvarez, JC (2016). Pharmacokinetics of oral fludrocortisone in septic shock. British journal of clinical pharmacology 82(6) 1509–1516. DOI:10.1111/bcp.13065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27416887