.Pharmacolibrary.Drugs.D_Dermatologicals.D08A_AntisepticsAndDisinfectants.D08AC02_Chlorhexidine.Chlorhexidine

Information

name:Chlorhexidine
ATC code:D08AC02
route:oral
n-compartments1

Chlorhexidine is a broad-spectrum antiseptic and disinfectant that is used to reduce bacteria on the skin and mucous membranes. It is commonly used for skin disinfection before surgery, wound cleaning, and as a mouthwash for oral hygiene. Chlorhexidine is approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters for chlorhexidine following oral administration in healthy adult volunteers (sex not specified; typical mucosal/skin and oral use).

References

  1. Toljanic, JA, et al., & Shapiro, RD (1992). Evaluation of the substantivity of a chlorhexidine oral rinse in irradiated head and neck cancer patients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 50(10) 1055–1059. DOI:10.1016/0278-2391(92)90490-q PUBMED:https://pubmed.ncbi.nlm.nih.gov/1527659

  2. Lim, SY, et al., & Heard, CM (2020). Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International journal of pharmaceutics 573 118860–None. DOI:10.1016/j.ijpharm.2019.118860 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31759104

  3. Salmanli, M, et al., & Tuzuner, T (2021). Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches. Computer methods and programs in biomedicine 212 106454–None. DOI:10.1016/j.cmpb.2021.106454 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34656905

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos