.Pharmacolibrary.Drugs.D_Dermatologicals.D08A_AntisepticsAndDisinfectants.D08AE03_Phenol.Phenol .Pharmacolibrary.Drugs.D_Dermatologicals.D08A_AntisepticsAndDisinfectants.D08AE03_Phenol.Phenol| name: | Phenol |
| ATC code: | D08AE03 | route: | topical |
| n-compartments | 1 |
Phenol (ATC D08AE03) is an aromatic organic compound with disinfectant and antiseptic properties. Historically used as a topical antiseptic, its use today is largely limited due to toxicity concerns, but it may still be used in some dermatological preparations and as a chemical cauterant for medical and minor surgical procedures. Phenol is not commonly used systemically as a drug in modern clinical practice.
Estimated pharmacokinetic parameters in adult humans based on toxicological and limited clinical data. No validated published PK model available for humans for the therapeutic use of phenol.
Sun, HF, et al., & Li, D (2018). Chemical Peeling with a Modified Phenol Formula for the Treatment of Facial Freckles on Asian Skin. Aesthetic plastic surgery 42(2) 546–552. DOI:10.1007/s00266-017-1048-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/29279953
Thelin, WR, et al., & Zoukhri, D (2012). Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4) 433–438. DOI:10.1089/jop.2011.0157 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22455658