.Pharmacolibrary.Drugs.D_Dermatologicals.D10A_AntiAcnePreparationsForTopicalUse.D10AE01_BenzoylPeroxide.BenzoylPeroxide .Pharmacolibrary.Drugs.D_Dermatologicals.D10A_AntiAcnePreparationsForTopicalUse.D10AE01_BenzoylPeroxide.BenzoylPeroxide| name: | BenzoylPeroxide |
| ATC code: | D10AE01 | route: | topical |
| n-compartments | 1 |
Benzoyl peroxide is a topical medication with antimicrobial and keratolytic properties, primarily used for the treatment of acne vulgaris. It is available over-the-counter and by prescription and is approved in many countries for current medical use in dermatology.
No direct pharmacokinetic studies in humans are available. Systemic absorption after topical administration is minimal, as the compound is largely converted to benzoic acid in the skin and rapidly excreted in the urine.
Ino, H, et al., & Hasegawa, S (2015). Systemic exposure to benzoic acid and hippuric acid following topical application of clindamycin 1%/benzoyl peroxide 3% fixed-dose combination gel in Japanese patients with acne vulgaris. Clinical pharmacology in drug development 4(1) 18–24. DOI:10.1002/cpdd.125 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27128000
Meredith, FM, & Ormerod, AD (2013). The management of acne vulgaris in pregnancy. American journal of clinical dermatology 14(5) 351–358. DOI:10.1007/s40257-013-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23996075