.Pharmacolibrary.Drugs.D_Dermatologicals.D10A_AntiAcnePreparationsForTopicalUse.D10AF03_Chloramphenicol.Chloramphenicol

Information

name:Chloramphenicol
ATC code:D10AF03
route:oral
n-compartments1

Chloramphenicol is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Once widely used, its application today is restricted due to the risk of serious adverse effects, notably aplastic anemia. It is still employed for the treatment of life-threatening infections such as typhoid fever and meningitis, particularly in resource-limited settings.

Pharmacokinetics

Reported pharmacokinetic parameters from adult patients after oral administration.

References

  1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

  2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

  3. Lugo Goytia, G, et al., & Mejía, CL (2000). Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters in pediatric patients with sepsis. The Annals of pharmacotherapy 34(3) 393–397. DOI:10.1345/aph.19050 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10917389

Revisions


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