.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G01A_AntiinfectivesAndAntisepticsExclCombinationsWith.G01AA03_AmphotericinB.AmphotericinB .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G01A_AntiinfectivesAndAntisepticsExclCombinationsWith.G01AA03_AmphotericinB.AmphotericinB| name: | AmphotericinB |
| ATC code: | G01AA03 | route: | intravenous |
| n-compartments | 2 |
Amphotericin B is a polyene antifungal agent used primarily in the treatment of severe, systemic fungal infections. It is considered a drug of choice for life-threatening mycoses, including cryptococcal meningitis and invasive candidiasis. Despite its effectiveness, it is associated with significant nephrotoxicity and infusion-related reactions. Conventional amphotericin B deoxycholate is still in use, while lipid formulations are also approved to reduce toxicity.
Pharmacokinetic parameters in adult patients with systemic fungal infections, administered intravenous amphotericin B deoxycholate (non-lipid formulation).
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